АЛГОРИТМЫ ПОИСКА МУТАЦИЙ ЛЕКАРСТВЕННОЙ УСТОЙЧИВОСТИ В ГЕНОМАХ МИКОБАКТЕРИЙ ТУБЕРКУЛЕЗА
Предлагается методология полногеномного поиска ассоциаций на примере геномов возбудителей туберкулеза, а также исследуются различные алгоритмы и подходы к оценке вклада мутаций в возникновение и развитие лекарственной устойчивости. Приводятся результаты экспериментов по поиску мутаций лекарственной устойчивости к основным противотуберкулезным препаратам на основании данных о пациентах из Беларуси.
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